Proteins and Derivatives
U-PLEX Human Clusterin ASY
The Meso Scale Discovery U-PLEX Human Clusterin Assay is an electrochemiluminescent immunoassay for the quantitative measurement of clusterin in human serum plasma and cell culture supernatants It utilizes MSD s proprietary U-PLEX technology is provided in a convenient all-in-one kit has a detection range of 50-10 000 pg/mL and exhibits high sensitivity specificity and reproducibility The assay requires a low sample volume of 50 L and provides results in under 5 hours It can be used to study clusterin levels in cancer neurodegenerative diseases and other research applications involving this multifunctional protein
Bovine Serum AlbuminBSA, 5g
New Zealand Precision Grade Bovine Serum Albumin product is an ideal choice for diagnostic and research applications where enhanced sensitivity is required due to low NEFA and high Monomer specifications ApplicationsDiagnostic amp research applications where enhanced sensitivity is required due to low NEFA specificationIdeal for sensitive IVD assays susceptible to background interferenceProtease-sensitive immunoassays such as RIA EIA fluorescent andchemiluminescentProtein standard diluentProtein conjugate or enzyme stabilizerHybridizationCell culture applications Including development of serum-free mediaFeatures/BenefitsHigh purity low interference low backgroundFatty acid freeVirtually no detectable protease activity ensures Assay Integrity Closed Loop manufacturing minimizes open air contamination amp maximizes lot-to-lot consistencySuperior solubility/filterability for ease of useManufactured according to FDA cGMPsSpecificationsProtein (dry basis) 98 0percentPurity (albumin) 98p
R-PLEX Mouse Clusterin ASY
The Meso Scale Discovery R-PLEX Mouse Clusterin Assay is a multiplex immunoassay panel that allows simultaneous measurement of Clusterin in mouse biological samples such as serum plasma and cell culture supernatants This assay utilizes MSD s electrochemiluminescence detection technology and provides high sensitivity up to 5 logs of dynamic range and low sample volume requirements The assay is provided in a convenient all-in-one kit including calibrators controls assay diluent read buffer and plate The R-PLEX Mouse Clusterin Assay allows for efficient and accurate quantification of the Clusterin biomarker
Cayman Chemical D-Galactose 1kg
A mixed-type non-competitive inhibitor of telomerase (IC50 93 nM) that has little effect on several mammalian DNA and RNA polymerases bacterial DNA helicase or HIV-1 reverse transcriptase induces senescence or apoptosis in cancer cells
Cayman Chemical Cholesteryl ArachIdonate 25mg
An alkaloid with diverse biological activities active against several strains of E histolytica amoebae (IC50s 0 73-10 22 g/ml) inhibits NF-KB signaling induced by TNF-a or IL-1B (IC50s 2 and 4 2 M respectively in a cell-basedBlactamase reporter assay) increases caspase-3/7 activity in ME180 cells (EC50 1 1 M) cytotoxic to HeLa cells reduces the infectious virus yield and viral RNA copy numbers in the culture supernatant of Vero E6 cells infected with SARS-CoV-2 (EC50s 0 46 and 0 5 M respectively) induces emesis in ferrets at 5 mg/kg an effect that can be prevented by ondansetron
Cayman Chemical AstragalosIde I 25mg
An anti-migraine agent binds to connexin43 hemichannels and inhibits ATP release in vitro during injury and reperfusion in a dose-dependent manner blocks trigeminal ganglion neuronal-satellite glial cell signaling and cortical spreading depression in vivo (10 mg/kg) increases the seizure threshold in MEST mice and rats (143 and 1192 respectively) blocks neurogenic plasma extravasation in a rat trigeminal nerve migraine model
Cayman Chemical SodIum Ionphore III 100mg
A macrotetrolide antibiotic that acts as an ionophore for monovalent cations such as K NH4 and Rb
Cayman Chemical Cholesteryl ArachIdonate 5mg
A class III antiarrhythmic agent inhibits IKr (IC50 10 UM) prolongs cardiac APD in isolated dog Purkinje fibers at 1 and 3 Ug/ml inhibits PES-induced arrhythmias in dogs post myocardial infarction increases atrial and ventricular ERPs in anesthetized dogs inhibits MATE1 (IC50 6 5 UM)
Cayman Chemical CalpaIn InhIbItr III 50mg
An analog of D-erythro-sphingosine inhibits PKC in mixed micelle assays with 50 inhibition at 2 2 mol making it a more potent inhibitor compared to D-erythro-sphingosine or other analogs of shorter alkyl chain length
Cayman Chemical Cholesteryl Butyrate 10g
A cationic lipid lipoplexes containing R-DOTAP and encapsulating siRNA targeting CYP19A1 decrease aromatase activity in MCF-7 cells vaccination with an HPV 16 protein E7 peptide in R-DOTAP-containing liposomes induces IFN-Y production by CD8 T cells and TILs and decreases tumor size in a murine cervical cancer model subcutaneous immunization with recombinant influenza B hemagglutinin using R-DOTAP as an adjuvant increases IL-2 and IFN-Y production in CD4 T cells isolated from mouse draining lymph nodes and spleen
RPLEX HUM Heme Oxygenase ASYQP
The R-PLEX Human Heme Oxygenase 1 Assay Kit from Meso Scale Discovery is a multiplex immunoassay that measures Heme Oxygenase 1 (HO-1) in human serum plasma and cell culture supernatants The assay uses electrochemiluminescence (ECL) detection technology and provides high sensitivity broad dynamic range and intra- and inter-assay precision This kit includes a 96-well plate coated with capture antibody detection antibody Read Buffer and calibrator It can test up to 80 samples in duplicate and only requires a small sample volume of 50 L The assay takes around 3 5 hours to complete
Cayman Chemical PIcrosIde I 50mg
A Pim kinase inhibitor that blocks mTORC1 activity via activation of AMPK killing a wide range of both myeloid and lymphoid cell lines (with IC50 values ranging from 0.8 to 40 M) induces G1 phase cell-cycle arrest dose-dependent induction of p27Kip1 apoptosis through the mitochondrial pathway and inhibition of the mTORC1 pathway at 10 M in pre–T-LBL cells
Cayman Chemical ChymostatIn 25mg
A naturally occurring diterpene that directly activates adenylyl cyclase to raise levels of cAMP in a wide variety of cell types binds to type 1 adenylyl cyclase membranes with an IC50 value of 41 nM and demonstrates an EC50 value of 0.5 M in an activation assay
U-PLEX Human Clusterin ASY
The Meso Scale Discovery U-PLEX Human Clusterin Assay is an electrochemiluminescent immunoassay for the quantitative measurement of Clusterin in human serum plasma and cell culture supernatants It utilizes MSD s proprietary U-PLEX technology is sensitive reproducible and provides results in just 3 5 hours The assay has a lower limit of detection of 0 03 ng/mL and an upper limit of 10 000 ng/mL It requires a low sample volume of 50 L The assay can be used to study Clusterin levels in cancer neurodegenerative diseases kidney diseases and for biomarker research
Cayman Chemical TIn IV ProtprphyrIn IX Chl 5mg
An analytical reference standard categorized as a benzofuran a potential metabolite of 4-MAPB and 4-EAPB based on the published metabolism of 5-MAPB intended for research and forensic applications